“Me and You and Everyone We Know” tells the story of Richard Swersey (John Hawkes) and Christine Jesperson (Miranda July) and how they get along in their daily lives.
Richard just separated from his wife and is taking care of his two sons when not working as a shoe salesman and Christine is struggling to become an artist and driving a cab for elderly people to make a living.
They fall in love with each other, a love at first sight sort of thing and a complicated one. The one just divorced and afraid to lose his children. The other yearning for the perfect man, expressing herself in ways no one else cares or is able to understand. They both find themselves at the crossroads of their lives. Which way will they turn?